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New Peer-Reviewed Publication of SpoonfulONE

August 07, 2020 3 min read

Changing behavior is a true challenge, and with feeding it's no different. As guidelines for food introduction reversed in recent years (goals are to introduce common allergens early and repeatedly), parents and pediatricians are catching up with making sure we get it done.

Numerous studies demonstrate the effectiveness of early introduction of a diverse diet to help reduce the risk of developing food allergies in babies, yet gaps remain on the practical implementation of these guidelines into the real world.1-4 

Holl et al., recently published in Pediatric Allergy and Immunology,  the first peer-reviewed study to demonstrate the acceptability by parents, and tolerability by healthy infants, of a daily serving of a powdered food mix-in containing 30 mg of protein from each of the 16 most commonly allergenic foods (SpoonfulONE). Notably, these 16 allergenic foods represent the coverage of over 90% of the US food-allergic pediatric population.

The study, a blinded, randomized, controlled 28-day trial was conducted by investigators at Northwestern University evaluated healthy infants in the United States, aged 5-11 months. A total of 705 infants were randomized 1:1 to powdered food mix-in (SpoonfulONE), containing 30 mg of or powdered placebo.

There were a total of 8,803 mix-ins and 8,087 placebo ingestions. During the duration of the study, no infant had any IgE-type reaction to the mix-in, nor to the placebo. In the statistical analysis, there was no significant difference between the groups in the proportion of any specific reported symptom (Table 3). 

The authors concluded that feeding a single daily dose of a multiple allergenic protein food supplements to healthy infants is accepted by parents, with a high study completion rate of 88%, equivalent in each arm. 

As pediatricians, we play a critical role in educating parents on all aspects of prevention, and the role of smart, multi-food introduction to help train your baby's growing tummy. Clinical evidence supports the preventable nature of food allergies when attention is paid to critical periods of immune development during infancy and toddlerhood. Recommendations have changed to guide parents to adopt the early and consistent introduction of a diverse diet of food allergens. 

This research can bring confidence to your recommendations of SpoonfulONE as a convenient solution for your parents to help consistently get all of these foods into babies and toddlers’ diets and maintain a diverse diet with over 90% coverage of food allergies.


About the Author

Wendy Sue Swanson, MD, MBE, FAAP is a pediatrician and Chief Medical Officer for SpoonfulONE. 


The full publication is available Open Access  HERE


  1. Du Toit G, Roberts G, Sayre PH, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Engl J Med. 2015;372(9):803-813. doi:10.1056/NEJMoa1414850
  2. Perkin MR, Logan K, Tseng A, et al. Randomized trial of introduction of allergenic foods in breast‐fed infants.N Engl J Med. 2016;374(18):1733‐1743.
  3. Roduit C, Frei R, Depner M, et al. Increased food diversity in the first year of life is inversely associated with allergic diseases. J Allergy Clin Immunol. 2014;133(4):1056-1064. doi:10.1016/j.jaci.2013.12.1044
  4. Tran MM, Lefebvre DL, Dai D, et al. Timing of food introduction and development of food sensitization in a prospective birth cohort. Pediatr Allergy Immunol. 2017;28(5):471-477. doi:10.1111/pai.12739
  5. Holl JL, Bilaver LA, Finn DJ, Savio K. A Randomized Trial of the Acceptability of a Daily Multi-Allergen Food Supplement for Infants. Pediatr Allergy Immunol. February 2020. doi:10.1111/pai.13223.